Active aging

Targeting Tissues with Extracellular Vescicles

This is never an all or nothing proposition, but rather the case that one tissue may take up half as […] The use of these vesicles as a basis for therapy is spreading.

Researchers here discuss the degree to which vesicles can be targeted to specific tissues via natural or artificial surface features. Much of cellular communication takes the form of secretion and uptake of extracellular vesicles, tiny membrane-wrapped packages of molecules. Since first generation stem cell therapies appear to produce their benefits via the signals generated by transplanted stem cells, why not use vesicles harvested from stem cells instead the cells themselves? The logistics are far less challenging, the costs lower.

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