Pep Guardiola's men look to be cruising to the Premier League title and will take a huge step closer to regaining the crown with three points over Ole Gunnar Solskjaer's side.
Follow Sportsmail's ALEX BOWMER for the action. Southampton travel to Sheffield United in the Premier League's Saturday 3pm match as they look to end their abysmal run.
Summary automatically generated by NewSUM A.I. from the following sources:
- Sheffield United vs Southampton – Premier League: Live score, lineups and updates (daily mail – mail online)
- Manchester City vs Man United – Premier League: Live score, lineups and updates (daily mail – mail online)