The passenger plane was flying from Moscow to the city of Orsk near the Kazakhstan border when it plummeted to the ground, state media said.
There were no survivors on the Saratov Airlines flight that when it went down about 50 miles southeast of the capital.
A Russian passenger plane crashed near Moscow soon after take-off on Sunday, killing all 71 people on board, and investigators said they were looking at all possible causes.
President Vladimir Putin ordered "relevant agencies to organize the search operation" after offering his condolences.
All Sources: New York Times Reuters NBC Deutsche Welle