It has long been hypothesized that aging and neurodegeneration are associated with somatic mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly. We used single-cell whole-genome sequencing to perform genome-wide somatic single-nucleotide variant (sSNV) identification on DNA from 161 single neurons from the prefrontal cortex and hippocampus of 15 normal individuals (aged 4 months to 82 years), as well as 9 individuals affected by early-onset neurodegeneration due to genetic disorders of DNA repair (Cockayne syndrome and xeroderma pigmentosum).
How do viruses that cause chronic infections, such as HIV or hepatitis c virus, manage to outsmart their hosts' immune systems? The answer to that question has long eluded scientists, but new research has uncovered a molecular mechanism that may be a key piece of the puzzle.
An international team of researchers has discovered a new quantitative relation that allows for quick identification of promising material combinations for organic solar cells.
Researchers have found a new way of accelerating wound healing.
The study also shows that significantly fewer of these patients die from heart disease.
sSNVs increased approximately linearly with age in both areas (with a higher rate in hippocampus) and were more abundant in neurodegenerative disease.
They say that SIFs save lives by bringing addiction out of the shadows.
The discovery could significantly reduce the 'trial and error' aspect of solar cell production by reducing the time spent on finding the most efficient mixtures.
The review is in response to growing evidence connecting environmental noise, including from road traffic and aircrafts, to the development of heart disease, such as coronary artery disease, arterial hypertension, stroke and heart failure.
Noise may disrupt the body on the cellular level in a way that increases the risk of common heart disease risk factors, according to a new review that examined the underlying mechanisms that may lead to noise-induced heart disease.
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