The storm, which strengthened to a Category 1 hurricane, is expected to make landfall in the U.S. between late Saturday night and early Sunday morning.
Local officials have warned that it "is the worst hurricane" to hit the area since Hurricane Katrina.
Hurricane Nate made landfall near the mouth of the Mississippi River as a Category 1 storm with winds of 85 miles per hour on Saturday evening, threatening parts of Louisiana, Mississippi and Alabama with torrential rain and flooding.
The storm has left at least 30 people dead and thousands more displaced since it swept through Central America.
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